Advocate dogs 4-10kg 3 pipettes | external antiparasitic spot-on solution

ADVOCATE

Spot Anointing Solution for Dogs

External antiparasitic in spot on solution

LABORATORY

BAYER HISPANIA, SL

PHARMACEUTICAL FORM

Spot-on anointing solution (Sol.udp)

COMPOSITION PER PIPETTE:

Imidacloprid 10% and moxidectin 2,5%. Butylhydroxytoluene.

PHARMACOLOGICAL PROPERTIES

Imidacloprid is an ectoparasiticide of the chloronicotinyl group, effective against the larval stages of fleas and adult fleas, with minimal pharmacological activity in mammals. It is quickly distributed on the animal's skin on the first day of application.

Moxidectin is a parasiticide of the milbemycin family (macrocyclic lactone) active against a large number of internal and external parasites, against the larval stages (L3, L4) of Dirofilaria immitis and against gastrointestinal nematodes. It is absorbed through the skin and distributed systemically, reaching peak plasma concentrations in approximately 4 to 9 days in dogs. It is slowly eliminated from the plasma.

INTERACTIONS AND INCOMPATIBILITIES

During treatment with Advocate, no other antiparasitic of the macrocyclic lactone type should be administered.

INDICATIONS AND TARGET SPECIES

Dogs: Treatment and prevention of infestations by fleas (Ctenocephalides felis), treatment of infestation by ear mites (Otodectes cynotis), treatment of circulating microfilariae (Diofilaria immitis). Prevention of heartworm disease (L3/L4 larvae of Dirofilaria immitis), subcutaneous heartworm disease (L3 larvae of Dirofilaria repens), spirocercosis (Spirocerca lupi) and angiostrongylosis (L4 larvae and immature adults of Angiostrongylus vasorum). Reduction of circulating microfilariae (Dirofilaria repens). Treatment of infections by gastrointestinal nematodes (L4 larvae, immature adults and adults of Toxocara canis, Ancylostoma caninum and Uncinaria stenocephala, adults of Toxascaris leonina and Trichuris vulpis). Treatment of infestation by chewing lice (Trichodectes canis), sarcoptic mange (Sarcoptes scabiei var. canis), demodicosis (Demodex canis) and infections by Angiostrongylus vasorum and Crenosoma vulpis. Strategic treatment of the DAPP.

CONTRAINDICATIONS

• Do not use in puppies less than 7 weeks.
• Do not use in case of hypersensitivity to the active substances or any of the excipients.
• Do not use in canaries.

SIDE EFFECTS

Advocate may cause transient itching in the dog.

Rarely, greasy hair, erythema, and vomiting may occur. These symptoms subside without treatment.

On rare occasions, local hypersensitivity reactions may occur.

If the animal licks the application area after treatment, transient neurological signs may rarely be observed.

The medicine has a bitter taste and if the animal licks it it can produce salivation. This effect is not a sign of poisoning and disappears after a few minutes without treatment.

Very rarely, the drug may give rise to a sensation at the point of application that causes transient behavioral disturbances such as lethargy, agitation, or loss of appetite.

ROUTE OF ADMINISTRATION

Topical.

POSOLOGY

Dogs: The minimum recommended dose is 0,1 ml of Advocate for dogs/kg. The entire contents of the pipette should be applied.

• Treatment and prevention of flea infestation: Once a month.
• Treatment of chewing lice infestation: A single dose.
• Heartworm prevention: Once a month.
• Treatment of infestation by ear mites: A single dose.
• Treatment of sarcoptic mange: A single dose twice, with an interval of 4 weeks.
• Treatment of demodicosis: A single dose every 4 weeks for a period of 2 to 4 months. In severe cases, more frequent and prolonged treatment may be required.
• Treatment and prevention of Angiostrongylus vasorum infection: A single dose.
• Treatment of Crenosoma vulpis infection: A single dose.
• Treatment of roundworm, hookworm and whipworm infections: Once a month.

SPECIAL PRECAUTIONS

For the animals:

• Treatment of dogs weighing less than 1 kg, as well as sick or weak animals, should be based on the veterinarian's benefit/risk assessment. Also, for use in pregnancy and lactation.
• The contents of the pipette or the applied dose should not come into contact with the eyes or mouth of the recipient animal and/or other animals. Do not let newly treated animals lick each other.
• In dogs of Collie, Bobtail and related breeds or their crosses, due to moxidectin, special care should be taken in the correct administration of the drug.
• Oral ingestion by the recipient animal and/or other animals in contact with it will be avoided.

For the person administering the medication:

• Avoid contact with skin, eyes and mouth.
• Do not eat, drink or smoke during application.
• Wash your hands well after using the medicine.
• After applying the medication, do not pet or groom the animals until the application site is dry.
• In case of accidental splash on the skin, wash immediately with soap and water. If it is about the eyes, they should be rinsed well with water.
• People with known hypersensitivity to any component should apply the drug with caution.
• In very rare cases, the drug may cause skin sensitization or transient skin reactions (eg allergy, irritation or tingling). If skin or eye symptoms persist or in case of accidental ingestion of the medicine, consult a doctor immediately and show him the package leaflet.

PRESERVATION MODE

Do not store at temperatures above 30 °C.

OBSERVATIONS

With veterinary prescription.

PRESENTATION

Package with 3 pipettes:

Advocate for small dogs 3 × 0,4 ml (=4 kg).

Advocate for medium dogs 3 × 1,0 ml (>4 10 kg).

Advocate for large dogs 3 × 2,5 ml (>10 25 kg).

Advocate for very large dogs 3 × 4,0 ml (>25 40 kg).

Package with 21 pipettes:

Advocate for small dogs 21 × 0,4 ml (=4 kg).

Advocate for medium dogs 21 × 1,0 ml (>4 10 kg).

DATA SHEET 

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